CNS Pathology

Central Nervous System Pathology (SITE IN DEVELOPMENT)

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FORUMHOMEHOMEThe Central Nervous System can be considered to be the neural networks present in the brain. These networks are fundamental to who we are as people. They allows us to think, feel emotions, experience sensation, learn, interact with the world and live. Damage to the CNS, caused by disease or trauma, can have profound implications to both physical and mental health. This website provides teaching resources detailing pathology of the brain, my experimental methods and my research publications. Please click on the "Teaching Resources" tab for information on specific diseases and background neuroscience.Click HERE for introductory videosOUR TEAMBIOGRAPHYAndrew Edwards, BSc, MResThe aim of my DPhil work was to find genetic mutations in mice which caused neuroanatomical defects in the hippocampus, cortex, corpus callosum, and ventricles. The rationale behind this was that such mutations would be informative about developmental neurobiology, the biological basis of behaviour and had the potential to provide insight into pathological mechanisms of numerous human neurological conditions.Previously, during my MRes, I researched the synapse as a target in the paediatric neurodegenerative contition known as neuronal ceroid lipofuscinosis.My primary research interest is the genetic basic of neurodevelopmental and neurodegenerative disease.I am currently studying a medical degree at the University of Dundee.TESTIMONIALSTEACHING RESOURCES (click on links below)Concepts1. Brain anatomy and physiology2. Terminology commonly used in pathology3. Disease types: progressive vs. congenital,Acute vs. chronic4. The role of genes in disease5.Enviromental factors in disease6. Finding new causes of disease through scienceSelected diseases1. Alzheimer's disease2. Cranial malformations3. Intellectual disability4. Multiple sclerosis5. Neuronal ceroid lipofusinosis6. Parkinson's disease7. Prion diseases8. StrokeClick HERE for lecture notes and class workClick HERE for Dundee facebook group resourcesSERVICES RESOURCESCONTACTCONTACTandrew.edwards_ccc.ox.ac.uk

Calbindin immunostaining

Gross brain morphology

Gallyas stain of whole brain

Gallyas stain of WT cerebellum

WT nissl stain

NeuN immunostained hippocampus

cilia.jpg

Golgi stain of dendritic spine

ALL RIGHTS RESERVED ANDREW EDWARDS 2011Site visitorscranial malformationsforumStrokeMultiple sclerosisIntellectual disabilityDundeeAlzheimersParkinsonsPrionsCeroid lipofuscinIntroductory videoBrain anatomy and physologyTerminologyDisease typesGenes and diseaseEnviroment and diseaseRole of scienceLectures and classes